"Foulkes Cancer Genetics LDI, Lady Davis Institute for Medical Researc - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 825925	NM_177438.3(DICER1):c.5729G>A (p.Arg1910Gln)	DICER1 (R1910Q)	Single nucleotide variant (3 prime UTR variant +1 more)	DICER1-related tumor predisposition	GUncertain significance FDA Recognized database
Select item 933132	NM_177438.3(DICER1):c.5692A>G (p.Arg1898Gly)	DICER1 (R1898G)	Single nucleotide variant (3 prime UTR variant +1 more)	not specified	GUncertain significance
Select item 653922	NM_177438.3(DICER1):c.5656G>A (p.Gly1886Arg)	DICER1 (G1886R)	Single nucleotide variant (3 prime UTR variant +1 more)	DICER1-related tumor predisposition	GUncertain significance FDA Recognized database
Select item 933131	NM_177438.3(DICER1):c.5622C>G (p.Tyr1874Ter)	DICER1 (T1820R +1 more)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 933130	NM_177438.3(DICER1):c.5604-1G>A	DICER1	Single nucleotide variant (splice acceptor variant)	not specified	GLikely pathogenic
Select item 825804	NM_177438.3(DICER1):c.5527+3A>G	DICER1	Single nucleotide variant (intron variant)	DICER1-related tumor predisposition	GLikely pathogenic FDA Recognized database
Select item 582239	NM_177438.3(DICER1):c.5504_5507del (p.Tyr1835fs)	DICER1 (Y1835fs)	Deletion (frameshift variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 933129	NM_177438.3(DICER1):c.5492G>A (p.Trp1831Ter)	DICER1 (W1831*)	Single nucleotide variant (nonsense +1 more)	not specified	GPathogenic
Select item 933128	NM_177438.3(DICER1):c.5489T>C (p.Val1830Ala)	DICER1 (V1830A)	Single nucleotide variant (missense variant +1 more)	not specified	GUncertain significance
Select item 30562	NM_177438.3(DICER1):c.5477C>A (p.Ser1826Ter)	DICER1 (S1826*)	Single nucleotide variant (nonsense +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 254350	NM_177438.3(DICER1):c.5465A>T (p.Asp1822Val)	DICER1 (D1822V)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GLikely pathogenic FDA Recognized database
Select item 933127	NM_177438.3(DICER1):c.5460C>G (p.Tyr1820Ter)	DICER1 (Y1820*)	Single nucleotide variant (nonsense +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933126	NM_177438.3(DICER1):c.5452G>A (p.Ala1818Thr)	DICER1 (A1818T)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GUncertain significance FDA Recognized database
Select item 933079	NM_177438.3(DICER1):c.5426_5442delinsCA (p.Gly1809_Ser1814delinsAla)	DICER1	Indel (inframe_indel +1 more)	DICER1-related tumor predisposition	GLikely pathogenic
Select item 412119	NM_177438.3(DICER1):c.5441C>T (p.Ser1814Leu)	DICER1 (S1814L)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 933125	NM_177438.3(DICER1):c.5439G>T (p.Glu1813Asp)	DICER1 (E1813D)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933124	NM_177438.3(DICER1):c.5439G>C (p.Glu1813Asp)	DICER1 (E1813D)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933093	NM_177438.3(DICER1):c.5439G>A (p.Glu1813=)	DICER1	Single nucleotide variant (synonymous variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933092	NM_177438.3(DICER1):c.5438A>T (p.Glu1813Val)	DICER1 (E1813V)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933091	NM_177438.3(DICER1):c.5438A>G (p.Glu1813Gly)	DICER1 (E1813G)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 933090	NM_177438.3(DICER1):c.5438A>C (p.Glu1813Ala)	DICER1 (E1813A)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GUncertain significance FDA Recognized database
Select item 933087	NM_177438.3(DICER1):c.5437_5438inv (p.Glu1813Ser)	DICER1 (E1813S)	Inversion (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933089	NM_177438.3(DICER1):c.5437G>C (p.Glu1813Gln)	DICER1 (E1813Q)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933088	NM_177438.3(DICER1):c.5437G>A (p.Glu1813Lys)	DICER1 (E1813K)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933086	NM_177438.3(DICER1):c.5429A>T (p.Asp1810Val)	DICER1 (D1810V)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933085	NM_177438.3(DICER1):c.5429A>G (p.Asp1810Gly)	DICER1 (D1810G)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933084	NM_177438.3(DICER1):c.5428G>T (p.Asp1810Tyr)	DICER1 (D1810Y)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GConflicting classifications of pathogenicity
Select item 933083	NM_177438.3(DICER1):c.5428G>C (p.Asp1810His)	DICER1 (D1810H)	Single nucleotide variant (missense variant +1 more)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 933082	NM_177438.3(DICER1):c.5428G>A (p.Asp1810Asn)	DICER1 (D1810N)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933081	NM_177438.3(DICER1):c.5427_5428delinsTT (p.Asp1810Tyr)	DICER1 (D1810Y)	Indel (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933080	NM_177438.3(DICER1):c.5426G>A (p.Gly1809Glu)	DICER1 (G1809E)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933078	NM_177438.3(DICER1):c.5425G>T (p.Gly1809Trp)	DICER1 (G1809W)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933077	NM_177438.3(DICER1):c.5425G>C (p.Gly1809Arg)	DICER1 (G1809R)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 661301	NM_177438.3(DICER1):c.5425G>A (p.Gly1809Arg)	DICER1 (G1809R)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 254349	NM_177438.3(DICER1):c.5394del (p.Glu1799fs)	DICER1 (E1799fs)	Deletion (frameshift variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933043	NM_177438.3(DICER1):c.5383G>A (p.Asp1795Asn)	DICER1 (D1795N)	Single nucleotide variant (missense variant +1 more)	not specified	GUncertain significance
Select item 933042	NM_177438.3(DICER1):c.5365-1G>T	DICER1	Single nucleotide variant (splice acceptor variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 659382	NM_177438.3(DICER1):c.5365-1G>A	DICER1	Single nucleotide variant (splice acceptor variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 1713278	NM_177438.3(DICER1):c.5365-4A>G	DICER1	Single nucleotide variant (intron variant)	DICER1-related tumor predisposition +1 more	GConflicting classifications of pathogenicity
Select item 933041	NM_177438.3(DICER1):c.5364+1187T>G	DICER1	Single nucleotide variant (intron variant)	DICER1-related tumor predisposition	GLikely pathogenic
Select item 933073	NM_177438.3(DICER1):c.4207-41_5364+1034del	DICER1	Deletion (splice acceptor variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 254343	NM_177438.3(DICER1):c.5096-498_5364+356del	DICER1	Deletion (splice acceptor variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 933040	NM_177438.3(DICER1):c.5347C>T (p.Gln1783Ter)	DICER1 (Q1783*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition	GPathogenic
Select item 933039	NM_177438.3(DICER1):c.5333del (p.Glu1778fs)	DICER1 (E1778fs)	Deletion (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 579687	NM_177438.3(DICER1):c.5330T>A (p.Leu1777His)	DICER1 (L1777H)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 242134	NM_177438.3(DICER1):c.5315_5316del (p.Phe1772fs)	DICER1 (F1772fs)	Deletion (frameshift variant)	DICER1-related tumor predisposition +1 more	GPathogenic
Select item 254348	NM_177438.3(DICER1):c.5299del (p.His1767fs)	DICER1 (H1767fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 254347	NM_177438.3(DICER1):c.5251_5255del (p.Lys1751fs)	DICER1 (K1751fs)	Deletion (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933038	NM_177438.3(DICER1):c.5221_5232del (p.Asn1741_Ile1744del)	DICER1	Deletion (inframe_deletion)	DICER1-related tumor predisposition	GLikely pathogenic
Select item 254346	NM_177438.3(DICER1):c.5194dup (p.Leu1732fs)	DICER1 (L1732fs)	Duplication (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933037	NM_177438.3(DICER1):c.5174G>A (p.Arg1725Gln)	DICER1 (R1725Q)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +1 more	GUncertain significance
Select item 933036	NM_177438.3(DICER1):c.5163T>A (p.Tyr1721Ter)	DICER1 (Y1721*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition	GPathogenic
Select item 221050	NM_177438.3(DICER1):c.5145C>T (p.Leu1715=)	DICER1	Single nucleotide variant (synonymous variant)	not specified +3 more	GBenign/Likely benign
Select item 933035	NM_177438.3(DICER1):c.5138A>C (p.Asp1713Ala)	DICER1 (D1713A)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 690454	NM_177438.3(DICER1):c.5138A>T (p.Asp1713Val)	DICER1 (D1713V)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GLikely pathogenic FDA Recognized database
Select item 933034	NM_177438.3(DICER1):c.5137G>A (p.Asp1713Asn)	DICER1 (D1713N)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933033	NM_177438.3(DICER1):c.5133T>G (p.Ile1711Met)	DICER1 (I1711M)	Single nucleotide variant (missense variant)	not specified	GLikely benign
Select item 932991	NM_177438.3(DICER1):c.5122_5128del (p.Gly1708fs)	DICER1 (G1708fs)	Deletion (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933032	NM_177438.3(DICER1):c.5127T>G (p.Asp1709Glu)	DICER1 (D1709E)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933031	NM_177438.3(DICER1):c.5127T>A (p.Asp1709Glu)	DICER1 (D1709E)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933030	NM_177438.3(DICER1):c.5126A>T (p.Asp1709Val)	DICER1 (D1709V)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 932992	NM_177438.3(DICER1):c.5125_5126delinsTG (p.Asp1709Cys)	DICER1 (D1709C)	Indel (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 477242	NM_177438.3(DICER1):c.5126A>G (p.Asp1709Gly)	DICER1 (D1709G)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 932994	NM_177438.3(DICER1):c.5125G>T (p.Asp1709Tyr)	DICER1 (D1709Y)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 932993	NM_177438.3(DICER1):c.5125G>C (p.Asp1709His)	DICER1 (D1709H)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 690480	NM_177438.3(DICER1):c.5125G>A (p.Asp1709Asn)	DICER1 (D1709N)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 254345	NM_177438.3(DICER1):c.5123G>A (p.Gly1708Glu)	DICER1 (G1708E)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +1 more	GPathogenic/Likely pathogenic
Select item 932990	NM_177438.3(DICER1):c.5115A>C (p.Glu1705Asp)	DICER1 (E1705D)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 932989	NM_177438.3(DICER1):c.5114A>T (p.Glu1705Val)	DICER1 (E1705V)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 932988	NM_177438.3(DICER1):c.5113G>C (p.Glu1705Gln)	DICER1 (E1705Q)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic
Select item 932987	NM_177438.3(DICER1):c.5113G>A (p.Glu1705Lys)	DICER1 (E1705K)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 254344	NM_177438.3(DICER1):c.5104C>T (p.Gln1702Ter)	DICER1 (Q1702*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition	GPathogenic FDA Recognized database
Select item 225884	NM_177438.3(DICER1):c.5103C>A (p.Tyr1701Ter)	DICER1 (Y1701*)	Single nucleotide variant (nonsense)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 580203	NM_177438.3(DICER1):c.5096-12G>A	DICER1	Single nucleotide variant (intron variant)	DICER1-related tumor predisposition	GLikely pathogenic FDA Recognized database
Select item 254342	NM_177438.3(DICER1):c.5095+1G>C	DICER1 (G1564A +1 more)	Single nucleotide variant (missense variant +1 more)	DICER1-related tumor predisposition	GPathogenic
Select item 479649	NM_177438.3(DICER1):c.5077C>A (p.His1693Asn)	DICER1 (H1693N)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +3 more	GUncertain significance
Select item 932986	NM_177438.3(DICER1):c.5065C>T (p.His1689Tyr)	DICER1 (H1689Y)	Single nucleotide variant (missense variant)	not specified	GUncertain significance
Select item 254341	NM_177438.3(DICER1):c.5053C>T (p.Gln1685Ter)	DICER1 (Q1685*)	Single nucleotide variant (nonsense)	Rhabdomyosarcoma, embryonal, 2 +1 more	GPathogenic
Select item 933123	NM_177438.3(DICER1):c.5023_5025delinsAG (p.Tyr1675fs)	DICER1 (Y1675fs)	Indel (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933122	NM_177438.3(DICER1):c.5018_5021del (p.Ile1673fs)	DICER1 (I1673fs)	Deletion (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933121	NM_177438.3(DICER1):c.5017dup (p.Ile1673fs)	DICER1 (I1673fs)	Duplication (frameshift variant)	not specified	GPathogenic
Select item 543602	NM_177438.3(DICER1):c.4999G>T (p.Glu1667Ter)	DICER1 (E1667*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition	GPathogenic
Select item 254340	NM_177438.3(DICER1):c.4960_4961dup (p.Asp1654fs)	DICER1 (D1654fs)	Duplication (frameshift variant)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 429127	NM_177438.3(DICER1):c.4923_4926del (p.Gly1640_Cys1641insTer)	DICER1	Deletion (nonsense)	DICER1-related tumor predisposition +1 more	GPathogenic
Select item 933120	NM_177438.3(DICER1):c.4910C>A (p.Ser1637Ter)	DICER1 (S1637*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition	GPathogenic
Select item 933119	NM_177438.3(DICER1):c.4889G>T (p.Arg1630Leu)	DICER1 (R1630L)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GUncertain significance FDA Recognized database
Select item 412061	NM_177438.3(DICER1):c.4888C>T (p.Arg1630Cys)	DICER1 (R1630C)	Single nucleotide variant (missense variant)	Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome +3 more	GConflicting classifications of pathogenicity
Select item 429128	NM_177438.3(DICER1):c.4812C>A (p.Cys1604Ter)	DICER1 (C1604*)	Single nucleotide variant (nonsense)	DICER1-related tumor predisposition +1 more	GPathogenic
Select item 933118	NM_177438.3(DICER1):c.4806C>T (p.Ala1602=)	DICER1	Single nucleotide variant (synonymous variant)	Hereditary cancer-predisposing syndrome +1 more	GConflicting classifications of pathogenicity
Select item 825165	NM_177438.3(DICER1):c.4775C>T (p.Pro1592Leu)	DICER1 (P1592L)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GUncertain significance FDA Recognized database
Select item 225883	NM_177438.3(DICER1):c.4754C>G (p.Ser1585Ter)	DICER1 (S1585*)	Single nucleotide variant (nonsense)	Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome +2 more	GPathogenic
Select item 4468	NM_177438.3(DICER1):c.4748T>G (p.Leu1583Arg)	DICER1 (L1583R)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GLikely pathogenic FDA Recognized database
Select item 412159	NM_177438.3(DICER1):c.4740G>T (p.Gln1580His)	DICER1 (Q1580H)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition	GLikely benign FDA Recognized database
Select item 933117	NM_177438.3(DICER1):c.4684_4685insC (p.Cys1562fs)	DICER1 (C1562fs)	Insertion (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 933116	NM_177438.3(DICER1):c.4651_4652insTGCT (p.Glu1551fs)	DICER1 (E1551fs)	Insertion (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 225885	NM_177438.3(DICER1):c.4633dup (p.Ser1545fs)	DICER1 (S1545fs)	Duplication (frameshift variant)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 254339	NM_177438.3(DICER1):c.4626del (p.Gln1542fs)	DICER1 (Q1542fs)	Deletion (frameshift variant)	DICER1-related tumor predisposition	GPathogenic
Select item 254338	NM_177438.3(DICER1):c.4621A>T (p.Lys1541Ter)	DICER1 (K1541*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +1 more	GPathogenic
Select item 242114	NM_177438.3(DICER1):c.4616C>T (p.Thr1539Met)	DICER1 (T1539M)	Single nucleotide variant (missense variant)	DICER1-related tumor predisposition +3 more	GConflicting classifications of pathogenicity
Select item 254337	NM_177438.3(DICER1):c.4605_4606del (p.Cys1535fs)	DICER1 (C1535fs)	Microsatellite (frameshift variant)	Vertebral anomalies and variable endocrine and T-cell dysfunction +3 more	GPathogenic

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